Orlistat (marketed under the trade name Xenical by Roche; or over-the-counter as alli by GlaxoSmithKline (pronounced /ˈælaɪ/, like the English word "ally")—also known as tetrahydrolipstatin—is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. It is intended for use in conjunction with a physician-supervised reduced-calorie diet.Orlistat is the saturated derivative of lipstatin—a potent natural inhibitor of pancreatic lipases isolated from the bacterium Streptomyces toxytricini. However, due to simplicity and stability, orlistat rather than lipstatin was developed into an anti-obesity drug.

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The Alii diet pill itself is a reduced strength version of the prescription weight loss drug Xenical (also known as Orlistat) which has an impressive safety record, and encouraging clinical trial results. In the original trials of Xenical .

The Weight Loss Institute offers information and sale of diet pills such as Phentermine, Xenical, Bontril and Meridia.