Wheat allergies are a group of allergies that have been connected to gluten sensitivity within humans. Globally, allergic diseases are growing in frequency, and among the allergens, wheat allergens have been identified as a more serious problem. Typical symptoms are urticaria, atopic eczema/dermatitis syndrome. Atypical allergic responses include anaphylaxis. Many conditions result from peripheral responses to ingested gluten. Gluten is more frequently a cause of allergic aggravation of rheumatoid arthritis and may also aggravate other autoimmune diseases.